Swept lasers have enabled paradigm-shifts in biomedical imaging and diagnostics. The SWEEPICS project will research and develop the next generation of swept source lasers with flexible pulse modulation capability, high power output, multi-wavelength coherent output and multi-application potential. SWEEPICS will develop new laser-based systems: a high-speed, high resolution multiphoton high content screening system, a multimodal non-invasive imaging system based on high-speed photoacoustics and multiphoton microscopy, and a smart microscope for accelerated acquisition&diagnostics. The inter-disciplinary consortium of European partners will showcase the SWEEPICS technology in cutting-edge use cases based on novel vascular organoids for animal-free drug-testing and infection studies. 

This disruptive SWEEPICS technology will rapidly generate high-resolution diagnostic imaging in three-dimension, where the high imaging depth permits penetrating millimeter deep into tissue-like organoids and imaging at high temporal and spatial resolution in order to allow for a drastic reduction of animal testing and increased speed of diagnostic results. It will allow the study of dynamic processes in real-time and at multiple length scales, enabling researchers to observe how cells and tissues respond to viral infections or pathogen-induced inflammation, while also permitting a high-throughput enabled discovery of novel diagnostic biomarkers.

Overall, this technology represents a major breakthrough in capable laser technology for high accuracy and throughput medical diagnostics and is poised to make significant contributions to the European laser and biomedical technology landscape.


  1. Develop agile, multi-capable swept source lasers
  2. Enable an AI-powered laser engine & smart microscopy system
  3. Develop deep & fast Multiphoton Microscopy on human cell-derived vascular organoids
  4. Develop an ultrahigh-speed opto-acoustic microscope for label-free & non-invasive blood oxygen Imaging
  5. Showcase SWEEPICS tools in five biomedical Use Cases
  6. Benchmark against state-of-the-art & disseminate technology
  7. Develop a Business model and exploit technology in different markets

Work packages:

In order to achieve the abovementioned objectives, the project plan is devised in ten work packages:

  1. Development of Experimental Lasers
  2. Development of Validation Lasers to TRL5
  3. Development of Multimodal Imaging Systems
  4. Development of On-site Validation Systems
  5. Use Cases: Organoids Manufacturing and Biomedical Applications
  6. Benchmarking
  7. Dissemination
  8. Exploitation and Business Strategies
  9. Management
  10. Ethics requirements